Home Today's Paper Most Popular Video Gallery Photo Gallery
Subscription Blog Signin Register
Logo
Sunday, February 25, 2018 07:51:33 PM
Follow Us On: Facebook Twitter Twitter Twitter Twitter

Trial of new anti-cancer drugs at Monash Pharmacy

photo by

By
03rd-Dec-2016       
Comments
Share your thought
Post a comment »
Read all () »

Life Desk :
Monash Pharmacy is ranked number 4 in the world (QS ranking 2016). As Australia's number one faculty of pharmacy and pharmaceutical sciences, Monash Pharmacy is at the forefront of both research and education in this field. Monash research undertaken by Australia's leading pharmaceutical scientists is having an impact on health around the globe. The prostate and bowel cancers are the biggest causes of cancer deaths in Australia.  A consortium of researchers at Monash University have been awarded a $2 million grant by the Victorian Cancer Agency (VCA) to start a Phase 11 clinical trial aimed at identifying which patients with bowel or prostate cancer respond well to a new suite of anti-cancer drugs called BET inhibitors.
The trial of 24 end-stage bowel and prostate cancer patients is expected to take three years - with the aim of finding biomarker, as well as an assay to detect them, that can predict which patients (as soon as they are diagnosed) will best respond to the BET inhibitor drug regime.
It is becoming increasingly clear that the genetic mutations that cause cancer do not necessarily occur early in life. In fact genetic mutations can occur throughout life and, in cancer, can occur at any stage, caused by a range of triggers from environmental, viral and chemical causes.
Prostate cancer in particular appears to undergo a lot of genetic changes quite late in its development, according to Professor Gail Risbridger, from the Monash Biomedicine Discovery Institute (BDI) and a member of the team.
The consortium will use the VCA grant to investigate a class of drugs, called BET inhibitors, which target the actual DNA of the tumour cells that has been shown to be successful in targeting cancer cells that have undergone these epigenetic changes.
Using unique banks of prostate and bowel cancer tissue the preclinical studies, run by Professor Risbridger and Associate Professor Helen Abud, also from BDI, the research team has retrospectively looked at which patients expressed responded to BET inhibitors and found markers they believe they can predict the "best responders"  to the therapy.
Having identified these markers the research team, led by Dr Arun Azad, from the Monash Faculty of Medicine, Nursing and Health Sciences, will conduct a three-year trial that biopsies patients to see whether they have markers associated with BET inhibitor responsiveness and then to follow these patients as they receive the treatment.
As data are collected from the patients who do and do not respond to the BET inhibitor therapy, the researchers will be able to look at the original biopsies to find markers that can predict the patients who are "good responders".
The Phase 11 trial is expected to begin within 12 months. Twenty four patients with Stage IV malignancy and the researchers expect to have a suite of markers associated with responders and non-responders to BET inhibitors within 24 months.

Tariff
Add Rate

News Archive

Inside The New Nation

International »

New strikes hit Syria enclave after UN delays truce vote


AFP, Beirut  :Air strikes and rocket fire hit the Syrian rebel enclave of Eastern Ghouta for a seventh straight day on Saturday after the United Nations again delayed a vote on a ceasefire.The Damascus government launched a devastating bombardment of the enclave just outside the capital last Sunday that has ...

Editorial »

More vigilance at Rohingya camps against human traffickers


Aid workers have identified 32 victims of human trafficking so far at Rohingya camps in Cox's Bazar and also reported lack of access to basic services and self-reliance opportunities - especially for women and girls increasing the risk of trafficking. If such risks were assessed from the very beginning when ...

Sports »

Medalist in the men's parallel giant slalom (from right) South Korea's Lee Sangho (silver), Switzerland's Nevin Galmarini (gold) and Slovenia's Zan Kosir (bronze) pose during their medals ceremony at the 2018 Winter Olympics in Pyeongchang, South Korea on Saturday.


Entertainment »

Sunny Leone on her Tamil film debut: I'm beyond excited to start shooting


Former adult film actress Sunny Leone made a swift move into the Hindi film industry in 2012. And now the Indo-Canadian actress is all set to make her debut in a Tamil film. She says south Indian films would help her grow as a person and an actress. Sunny, whose ...

City »

Poet Abdul Hai Shikder along with others holds the copies of a book titled 'Aroni' written by Latiful Khabira at its cover unwrapping ceremony in the city's Suhrawardy Udyan on Saturday.


Editorial »

Indian Army Chief`s allegation means complicity of government of Bangladesh


REMARKS by Indian Army Chief, Gen. Bipin Rawat on Thursday that a 'planned influx' of people from Bangladesh into India's north-east is underway as part of a proxy war by Pakistan with support from China, so to keep the area disturbed. Moreover, he also said migration from Bangladesh are happening ...

Sports »

Bronze medalist in the women`s Big Air snowboard Synnott Zoi Sadowski of New Zealand, poses during the medals ceremony at the 2018 Winter Olympics in Pyeongchang, South Korea on Thursday.


.

Entertainment »

Priyanka Chopra terminates contract with Nirav Modi, not suing him yet


Priyanka Chopra has decided to cut ties with billionaire diamond trader Nirav Modi's brand following the news about the alleged banking fraud carried out by him. "In the light of recent allegations, Priyanka Chopra has chosen to terminate her contract with the Nirav Modi brand," a spokesperson of Priyanka, who ...

City »

BNP Standing Committee Member Barrister Moudud Ahmed speaking at a protest rally organised by Khaleda Zia Mukti Parishad at the Jatiya Press Club on Friday demanding release of BNP Chairperson Begum Khaleda Zia.


.

International »

Ex-Trump campaign associates face more charges


AP, Washington  :Dramatically escalating the pressure and stakes, special counsel Robert Mueller filed additional criminal charges Thursday against President Donald Trump's former campaign chairman and his business associate.The filing adds allegations of tax evasion and bank fraud and significantly increases the legal jeopardy facing Paul Manafort, who managed Trump's campaign ...

Front Page »

Amnesty accuses President Trump of HR violations


Human rights group Amnesty International has accused Donald Trump of "hateful" politics and of being a threat to human rights. "President Trump takes actions that violate human rights at home and abroad," the group said. Amnesty put Mr Trump in the same group as the leaders of Egypt, Russia, China, ...

Editorial »

Serving people not making money must be the motto


PHYSICIANS must provide treatment, President Abdul Hamid said to common people at affordable cost so that no one remained deprived of receiving treatment for lack of money. He made the call while addressing the third convocation of Bangabandhu Sheikh Mujib Medical University in the city on Monday. He has also ...

Sports »

Karolina Pliskova of Czech Republic celebrates after she beats Carla Suarez Navarro of Spain during the Dubai Duty Free Tennis Championship in Dubai, United Arab Emirates on Wednesday.


Entertainment »

Alicia Vikander loves `big adventure films`


Oscar-winning actress Alicia Vikander said she loves "independent and arthouse" cinema, but is also attracted towards the big adventure films.The actress, who will be soon seen as Lara Croft in the forthcoming film 'Tomb Raider', also shared that she found training and muscle-building exercise for the role, empowering. "My mother, ...

International »

Merkel calls for Europe to step up to global challenges


Reuters, Berlin  :The European Union must develop a response to growing global political and economic pressures and this will be the spirit of an EU summit this week, German Chancellor Angela Merkel said on Thursday.Merkel pointed to the crisis in Syria and the growing importance of Asian economies as needing ...

 
Items that you save may be read at any time on your computer, iPad, iPhone or Android devices.
 
Are you new to our website? Do you have already an account at our website?
Create An Account Log in here
Email this news to a friend or like someone
Email:
Write a comment to this news