Home Today's Paper Most Popular Video Gallery Photo Gallery
Subscription Blog Signin Register
Logo
Saturday, April 21, 2018 12:27:14 AM
Follow Us On: Facebook Twitter Twitter Twitter Twitter

Protein found effective against Parkinson's disease

photo by

By
31st-Dec-2016       
Comments
Share your thought
Post a comment »
Read all () »

Life Desk :
Scientists working on neurodegenerative diseases have identified a key protein, Nrf2, that prevents the accumulation of proteins that damage the neurons in the brain.
Both LRRK2 or a-synuclein proteins that are implicated in Parkinson's and Alzheimer's, after the addition of Nrk2, were either clumped together or removed from the cell, preventing damage to the cell.
Nrk2 has the potential to be used as the first treatment measure for neurodegenerative disorders.
A key cellular protein identified by latest research studies could be the cure for many neurodegenerative disorders like Huntington's, Parkinson's, Alzheimer'sand Amyotrophic Lateral Sclerosis These disorders are caused by protein folding and accumulation in the neurons, resulting in the damage to the cells and finally destruction.
Dr. Steven Finkbeiner and colleagues from The Gladstone Institute used another protein called the Nrf2 which brings the rogue, disease causing proteins in the brain to normal levels, thus avoiding damage and killing of essential neurons.
'Nrf2 is a key protein can remove toxic proteins and could be effective against neurodegenerative diseases'
The protein was tested on two versions of Parkinson's disease cells, one type of cells with mutations in the protein LRRK2 and the other type of cells with mutations in the protein a-synuclein. The researchers found that when the protein Nrf2 was activated, it lead to a 'housekeeping' of the cell that resulted in removal of the excess of LRRK2 and a-synuclein.
Dr. Gaia Skibinski who is the first author of the study and a staff research scientist at Gladstone Institute says that Nrf2 has always been known to regulate gene expression but its function in lowering levels of other proteins was not known till now. The overexpression of the protein Nrf2 was found to be very beneficial in Parkinson's disease and protected the cells from damage much better than any method till date.
The study was published in the Journal Proceedings of the National Academy of Sciences detailing the effect of the protein Nrf2 in lowering the levels of other proteins. In the study, both rat neurons and human neurons were induced from pluripotent stem cells.
The neuron cells were programmed to express
Nrf2 protein
Either LRRK2 or a-synuclein protein
The researchers used a microscope that was developed by the Finkbeiner laboratory to study the cells that were tagged to monitor the level of protein. The overall health of the cells was also monitored. The researchers took many pictures of the cells, from development till they died.
The protein Nrf2 worked in differing ways to lower levels of the two proteins
For cells with mutant LRRK2, the LRRK2 proteins were clumped together and they remained in the cell without damaging it.
For cells with mutant a-synuclein, the a-synuclein breakdown was accelerated and the protein cleared from the cells.
Dr. Finkbeiner who is the senior author of the study said that he was very excited about this research study and that they had used the protein Nrf2 on cells with Parkinson's, Huntington's and ALS and found effective protection which was not identified with any other method of protection. The senior researcher further added "Based on the magnitude and the breadth of the effect, we really want to understand Nrf2 and its role in protein regulation better".
The identification of the protein Nrf2 is significant in the research studies on neurodegenerative diseases. It holds promise in the treatment of these diseases, however, the protein cannot be used as the target for drug therapy. This is because the protein is involved in multiple metabolic processes. The scientists are looking at downstream elements which could act as possible targets.
Nrf2:
The Nrf2 is the nuclear factor erythroid 2 protein that is involved in antioxidant signaling. This protein controls basal as well as induced protein in the array of antioxidant response element- developmental genes to regulate the response to anti-oxidants.
These proteins are not involved in blood cell differentiation but they are found to regulate certain drug metabolizing enzymes. Their primary role is in the resistance to oxidative stress. The protein is known to be anti-inflammatory and results in age dependent autoimmunity in mice. There are many benefits that have been identified, the most important being in chronic obstructive pulmonary disease (COPD). Heavy cigarette smokers are at an increased risk of getting COPD, but the protein Nrf2 is found to be protective against damage to the lungs.
The protective effect of this protein has been well established; the current study that unearthed benefits in neurodegenerative disorders will have a profound effect on the treatment and care of these diseases. Neurodegenerative disorders are debilitating conditions that affect the quality of life of the individual, but there is no known cure for these conditions yet. The use of this protein in the treatment of these diseases could help treat the conditions. Further studies could detail whether the use of this protein as a preventive medicine restricts accumulation of toxic proteins in the brain that leads to neuronal damage.
Source: Medindia

Tariff
Add Rate

News Archive

Inside The New Nation

Editorial »

No law can restrict freedom of speech


EDITORS' COUNCIL, an organisation of editors of the country's national dailies, has recently expressed grave concern over Section 21, 25, 28, 31, 32, and 43 of the Proposed Digital Security Act. It said the sections would greatly obstruct freedom of speech and independent journalism. However, responding to the concern the ...

Football »

Manchester United`s Paul Pogba (second right) and Bournemouth's Steve Cook battle for the ball, during the English Premier League soccer match between Bournemouth and Manchester United, at the Vitality Stadium in Bournemouth, England on Wednesday.


.

City »

General Secretary of Bangladesh Sarak Paribahan Sramik Federation Osman Ali, among others, at a rally of labourers in Swadhinata auditorium of DRU on Friday demanding implementation of five thousand CNG registration allocated for drivers.


.

Entertainment »

Anny pairs up with Zahid Hasan for first time


Entertainment Report :Popular actress and model of present time Anny Khan for the first time paired up with National Film Award winner actor and director Zahid Hasan in a drama serial.Zahid Hasan is acting in the title role in the serial. Viewers will watch a new role Zara in the ...

International »

Koreas set up 1st hotline between leaders ahead of summit


AP, Seoul :North and South Korea installed the first-ever telephone hotline between their leaders Friday as they prepare for a rare summit next week aimed at resolving the nuclear standoff with Pyongyang.South Korea's presidential office said a successful test call was conducted on the hotline between Seoul's presidential Blue House ...

Editorial »

Lawlessness in the transport sector


RAJIB Hossain, a third-year student of Titumir College, whom right hand was pulled out being stuck between two speeding buses in the city, drifted off to death on Tuesday after two weeks in coma. The life of the ill-fated youth ended quite tragically at 21 leaving his two teenage brothers ...

Football »

Real Madrid's Cristiano Ronaldo gestures during a Spanish La Liga soccer match between Real Madrid and Athletic Bilbao at the Santiago Bernabeu stadium in Madrid on Wednesday.


Entertainment »

Sudden rendezvous of Afsana Mimi, Zahid Hasan


Entertainment Report :Hothat Dekha (sudden rendezvous) is not a title. It was a sudden rendezvous of two friends, two popular actors and directors - Afsana Mimi and Zahid Hasan.  Recently they were taking part in shooting of two separate plays in the city’s Uttara area. Zahid Hasan was engaged with ...

Entertainment »

Momo appears as Alta today


Sheikh Arif Bulbon :National Film Award winner actress Zakia Bari Momo acted and Arun Chowdhury directed movie Altabanu releases today. In this movie, Momo acted in role of Alta against Anisur Rahman Milon. Farzana Rikta acted in role of Alta’s younger sister Banu. Including Dhaka this movie is set to ...

City »

Chief Election Commissioner KM Nurul Huda speaking at a seminar on 'Giving National Identity Cards among Expatriate Bangladeshis and Voting Rights' organised by Bangladesh Election Commission at Sonargaon Hotel in the city on Thursday.


International »

UN in talks with Syria, Russia on security for chemical weapons experts


AFP, United Nations :A UN team is discussing security arrangements with Syrian and Russian authorities in Douma to allow experts to deploy soon to investigate an alleged chemical weapons attack, UN security officials said Wednesday.The fact-finding mission from the Organisation for the Prohibition of Chemical Weapons (OPCW) to the Syrian ...

Editorial »

Ensure proper working atmosphere in RMG sector


WORKERS at more than 3,000 subcontracting readymade garment factories in Bangladesh have been working under dangerous conditions even five years after Rana Plaza collapse as the factories still lack of safety measures, according to a recent study of New York University. The study titled 'Five Years After Rana Plaza: The ...

Football »

Draw ceremony of SAFF Championship held


Sports Reporter :The draw ceremony of SAFF Championship was held at the Pan Pacific Sonargaon Hotel in the city on Wednesday.President of BFF and President of SAFF Kazi Md Salahuddin, Regional Country Manager of Maruti Suzuki Seije Hamda, Senior Vice-President of BFF Abdus Salam Murshedy, Vice-President of BFF Kazi Nabil ...

Sports »

The Thailand-bound Bangladesh Hockey team pose for photo at the Falcon Hall of Bangladesh Air Force Office in the city's Tejgaon on Wednesday.


Entertainment »

Is Natasha Suri Lady Luck for Dwayne Bravo?


A few days ago Natasha Suri and Dwayne Bravo were spotted laughing and chatting away animatedly, in spite of the attention of on-lookers and fans at a SoBo coffee shop. She was also spotted in the VIP box watching the IPL match the next evening at Wankhede Stadium in Mumbai. ...

 
Items that you save may be read at any time on your computer, iPad, iPhone or Android devices.
 
Are you new to our website? Do you have already an account at our website?
Create An Account Log in here
Email this news to a friend or like someone
Email:
Write a comment to this news