Home Today's Paper Most Popular Video Gallery Photo Gallery
Subscription Blog Signin Register
Logo
Thursday, March 23, 2017 08:18:17 AM
Follow Us On: Facebook Twitter Twitter Twitter Twitter

Autism-cancer link identified

photo by

By
17th-Mar-2017       Readers ( 73 )   0 Comments
Comments
Share your thought
Post a comment »
Read all (0) »

Life Desk :
SHANK protein prevents the ability of cancer cells to adhere and migrate to surrounding tissue. But in autism there is the absence or gene mutations associated with SHANK proteins.
Gene mutations in SHANK, found in autistic patients, impair SHANKs ability to prevent the adherence of both neurons and breast cancer cells.
An unexpected link between cancer and autism has been discovered..
Researchers from Turku Centre for Biotechnology have observed that a protein called SHANK prevents the spread of breast cancer cells to the surrounding tissue by regulating the cell shape and adhesion in very different cell types.
'The SHANK protein involved in several processes in the central nervous system also prevents the cancer cell adhesion and migration to surrounding tissue.'
It prevented the ability of cancer cells to adhere and migrate on their environment and invade into surrounding tissue.
The SHANK protein has been previously been intensively studied in several processes in the central nervous system, and it is known that its absence or gene mutations are related to autism.
The findings revealed that in autistic patients with gene mutations in SHANK, impairs the ability of SHANK to prevent the adherence of both neurons and breast cancer cells.
Rap1 proteins activate cell adhesion receptors called integrins.
In cell culture experiments, the researchers found that SHANK protein limits the ability of the protein called Rap1 to activate integrins.
But gene mutations of SHANK which impairs its ability, triggers increases Rap1 activity, cell spreading, migration and invasion in cancer.
The same mechanism that regulated cancer cell motility is applicable to the morphology and branching of neurites, known to be essential for normal brain function.
The research team is currently assessing the impact of SHANK proteins on cancer cells, especially on their proliferation.
The findings were published in Nature Cell Biology.
Source: Medindia

0 Comments. Share your thoughts also.
Write a comment
Tariff
Add Rate

News Archive

Inside The New Nation

Editorial »

Digging city roads facing monsoon is intriguing


FACING the arrival of monsoon two Dhaka City Corporation (DCC) authorities have permitted different utility service providers to dig up road surface without taking into account that it will cause heavy traffic congestion and immense suffering to city dwellers. Utility providers like Dhaka Water Supply & Sewerage Authority (DWASA), have ...

City »

Bangladesh Federal Union of Journalists (BFUJ) and Dhaka Union of Journalists (DUJ) jointly brought out a rally yesterday towards the Office of the Prime Minister demanding immediate declaration of 9th Wage Board and later submitted memorandum to the Prime Minister.


.

Football »

Mexico`s Nestor Araujo (left) and Javier Hernandez practice during a training session in Cuernavaca, Mexico on Tuesday. Mexico will face Costa Rica in a 2018 World Cup qualifying soccer match on March 24.


.

Entertainment »

When people deter me, it only makes me stronger: Anushka Sharma


Hate begets hate. Positivity spawns positivity and failure is just one more step in our march to success - this is the mantra that Anushka Sharma lives by. She shrugs off slander, laughs away at the evils of social media and confesses that she didn’t have a clear vision from ...

International »

Afghanistan wants more US help in fight against Taliban, IS


AP, Washington :Afghanistan wants the United States to send more forces to help meet shortfalls in the battle against the Taliban and the Islamic State group, the nation's top diplomat said Tuesday.Foreign Minister Salahuddin Rabbani welcomed a recent call by U.S. Gen. John Nicholson, the top American commander in Afghanistan, ...

Editorial »

End strike at BD Medical to end patients suffering


DOCTORS at Bangladesh Medical College Hospital (BMCH) are evidently causing havoc on patients as they continued strike for the past one-week on trivial issues. We must say there may be conflict in many issues between doctors and their parent body Bangladesh Medical Studies and Research Institute (BMSRI), but shutting the ...

Sports »

The Tamil Nadu players pose with the Vijay Hazare Trophy after their win against Bengal in final at Delhi on Monday.


.

International »

Trump admin weighing broad sanctions on North Korea


Reuters, Washington :The Trump administration is considering sweeping sanctions aimed at cutting North Korea off from the global financial system as part of a broad review of measures to counter Pyongyang's nuclear and missile threat, a senior U.S. official said on Monday.The sanctions would be part of a multi-pronged approach ...

City »

Visitors at a photo exhibition organised on the occasion of 98th birthday of Bangabandhu Sheikh Mujibur Rahman at Azimpur School playground in the city on Tuesday.


.

Entertainment »

Rani Mukerji`s first interview post- motherhood, she talks about everything


Rani Mukerji took a break from the life she knew to concentrate on the life she made - Adira. She was immersed in motherhood, and movies were nowhere in the picture. Now that the queen has committed to a film, she is coming out of her self-imposed exile. As she ...

Editorial »

Privatization of SOBs not solution to mismanagement


THE continuous losses of State-Owned Banks (SOBs) prompted the government to consider privatising them all, expect one, said media report on Monday. Most State-Owned Banks are now sustaining on tax-payer-funded money. Finance Minister AMA Muhith discussed the government's thinking in presence of the Managing Directors of all seven State Owners ...

Cricket »

Australia`s Shaun Marsh (right) and Peter Handscomb run between the wickets to score runs during the fifth day of their third test cricket match against India in Ranchi, India on Monday.


Entertainment »

Anny hosting five shows in four channels


Sheikh Arif Bulbon :This time some TV actresses engage themselves with hosting in different TV shows. Popular model and TV actress Anny Khan has been engaged with hosting many days ago. For this reason, she is frequently seen on the screen as a host rather than other regular hosts. Not ...

Entertainment »

Juhi Chawla would love for her kids to become actors, but they’re not interested


Actor Juhi Chawla would love to see her children - daughter Jhanvi (16) and son Arjun (14) - follow her footsteps, and take up a career in films. But the 49-year-old isn’t sure if that would ever happen, as her kids are way too shy, and Bollywood doesn’t seem to ...

City »

BNP Secretary General Mirza Fakhrul Islam Alamgir, among others, at a discussion on `Role of Shaheed Zia in Liberation War and Present Political Situation` organised by National Peopl`s Party at DRU auditorium on Monday.


 
Items that you save may be read at any time on your computer, iPad, iPhone or Android devices.
 
Are you new to our website? Do you have already an account at our website?
Create An Account Log in here
Email this news to a friend or like someone
Email:
Write a comment to this news