Home Today's Paper Most Popular Video Gallery Photo Gallery
Subscription Blog Signin Register
Logo
Monday, February 26, 2018 03:10:44 AM
Follow Us On: Facebook Twitter Twitter Twitter Twitter

Autism-cancer link identified

photo by

By
17th-Mar-2017       
Comments
Share your thought
Post a comment »
Read all () »

Life Desk :
SHANK protein prevents the ability of cancer cells to adhere and migrate to surrounding tissue. But in autism there is the absence or gene mutations associated with SHANK proteins.
Gene mutations in SHANK, found in autistic patients, impair SHANKs ability to prevent the adherence of both neurons and breast cancer cells.
An unexpected link between cancer and autism has been discovered..
Researchers from Turku Centre for Biotechnology have observed that a protein called SHANK prevents the spread of breast cancer cells to the surrounding tissue by regulating the cell shape and adhesion in very different cell types.
'The SHANK protein involved in several processes in the central nervous system also prevents the cancer cell adhesion and migration to surrounding tissue.'
It prevented the ability of cancer cells to adhere and migrate on their environment and invade into surrounding tissue.
The SHANK protein has been previously been intensively studied in several processes in the central nervous system, and it is known that its absence or gene mutations are related to autism.
The findings revealed that in autistic patients with gene mutations in SHANK, impairs the ability of SHANK to prevent the adherence of both neurons and breast cancer cells.
Rap1 proteins activate cell adhesion receptors called integrins.
In cell culture experiments, the researchers found that SHANK protein limits the ability of the protein called Rap1 to activate integrins.
But gene mutations of SHANK which impairs its ability, triggers increases Rap1 activity, cell spreading, migration and invasion in cancer.
The same mechanism that regulated cancer cell motility is applicable to the morphology and branching of neurites, known to be essential for normal brain function.
The research team is currently assessing the impact of SHANK proteins on cancer cells, especially on their proliferation.
The findings were published in Nature Cell Biology.
Source: Medindia

Tariff
Add Rate

News Archive

Inside The New Nation

Editorial »

Female Nobel Laureates by the side of Rohingya women


THREE female Nobel Peace Laureates are in city on a weeklong trip to Bangladesh to see for themselves Rohingya women who were tortured and raped by Myanmar military before fleeing refugee camps in our country. During their visit, Iran's Shirin Ebadi, Yemen's Tawakkol Karman and Northern Ireland's Mairead Maguire have ...

Cricket »

Members of CAD Challengers, who became champions of NBL Internal Cricket Tournament pose for photo with the trophy and officials at Dhaka University Central Ground on Friday (Feb 23). In the final CAD Challengers defeated Western Spirit by 7 wickets.


Entertainment »

Abhishek Kapoor, Sara & Sushant's Kedarnath is on course!


Sushant Singh Rajput took to social media and posted a team picture with so-star Sara and director, producer Abhishek Kapoor captioning it as Jai Shiv Shambhoo recently. The trio were all smiles while posing for the click. The lead pair had visited Abhishek at his office located in the suburbs ...

Entertainment »

Veteran actress Sridevi dies of cardiac arrest


Entertainment Report :Veteran Bollywood actor and Padma Shri awardee Sridevi, who had an illustrious career spanning over four decades, passed away. She was 54. Sridevi, died late in the night reportedly due to cardiac arrest in Dubai, where she had gone along with her family to attend her nephew Mohit ...

City »

Lawyers of BNP Chairperson Begum Khaleda Zia briefing media people after hearing on bail of Khaleda Zia in Zia Orphanage Trust Graft Case coming out of the court on Sunday.


International »

China sets stage for Xi to stay in office indefinitely


sReuters, Beijing :China's ruling Communist Party on Sunday set the stage for President Xi Jinping to stay in office indefinitely, with a proposal to remove a constitutional clause limiting presidential service to just two terms in office.Xi, 64, is currently required by the country's constitution to step down as president ...

International »

New strikes hit Syria enclave after UN delays truce vote


AFP, Beirut  :Air strikes and rocket fire hit the Syrian rebel enclave of Eastern Ghouta for a seventh straight day on Saturday after the United Nations again delayed a vote on a ceasefire.The Damascus government launched a devastating bombardment of the enclave just outside the capital last Sunday that has ...

Editorial »

More vigilance at Rohingya camps against human traffickers


Aid workers have identified 32 victims of human trafficking so far at Rohingya camps in Cox's Bazar and also reported lack of access to basic services and self-reliance opportunities - especially for women and girls increasing the risk of trafficking. If such risks were assessed from the very beginning when ...

Sports »

Medalist in the men's parallel giant slalom (from right) South Korea's Lee Sangho (silver), Switzerland's Nevin Galmarini (gold) and Slovenia's Zan Kosir (bronze) pose during their medals ceremony at the 2018 Winter Olympics in Pyeongchang, South Korea on Saturday.


Entertainment »

Sunny Leone on her Tamil film debut: I'm beyond excited to start shooting


Former adult film actress Sunny Leone made a swift move into the Hindi film industry in 2012. And now the Indo-Canadian actress is all set to make her debut in a Tamil film. She says south Indian films would help her grow as a person and an actress. Sunny, whose ...

City »

Poet Abdul Hai Shikder along with others holds the copies of a book titled 'Aroni' written by Latiful Khabira at its cover unwrapping ceremony in the city's Suhrawardy Udyan on Saturday.


Editorial »

Indian Army Chief`s allegation means complicity of government of Bangladesh


REMARKS by Indian Army Chief, Gen. Bipin Rawat on Thursday that a 'planned influx' of people from Bangladesh into India's north-east is underway as part of a proxy war by Pakistan with support from China, so to keep the area disturbed. Moreover, he also said migration from Bangladesh are happening ...

Sports »

Bronze medalist in the women`s Big Air snowboard Synnott Zoi Sadowski of New Zealand, poses during the medals ceremony at the 2018 Winter Olympics in Pyeongchang, South Korea on Thursday.


.

Entertainment »

Priyanka Chopra terminates contract with Nirav Modi, not suing him yet


Priyanka Chopra has decided to cut ties with billionaire diamond trader Nirav Modi's brand following the news about the alleged banking fraud carried out by him. "In the light of recent allegations, Priyanka Chopra has chosen to terminate her contract with the Nirav Modi brand," a spokesperson of Priyanka, who ...

City »

BNP Standing Committee Member Barrister Moudud Ahmed speaking at a protest rally organised by Khaleda Zia Mukti Parishad at the Jatiya Press Club on Friday demanding release of BNP Chairperson Begum Khaleda Zia.


.

 
Items that you save may be read at any time on your computer, iPad, iPhone or Android devices.
 
Are you new to our website? Do you have already an account at our website?
Create An Account Log in here
Email this news to a friend or like someone
Email:
Write a comment to this news