Home Today's Paper Most Popular Video Gallery Photo Gallery
Subscription Blog Signin Register
Logo
Thursday, June 21, 2018 06:54:56 AM
Follow Us On: Facebook Twitter Twitter Twitter Twitter

Vitamin C may stave off blood cancer

By
26th-Aug-2017       
Comments
Share your thought
Post a comment »
Read all () »

Life Desk :
Vitamin C injections may halt the progression of blood cancer by encouraging faulty stem cells in the bone marrow to die, a study in mice has found. Certain genetic changes are known to reduce the ability of an enzyme called TET2 to encourage stem cells to become mature blood cells, which eventually die, in many patients with certain kinds of leukemia, researchers said. "We are excited by the prospect that high-dose vitamin C might become a safe treatment for blood diseases caused by TET2-deficient leukemia stem cells, most likely in combination with other targeted therapies," said Benjamin Neel, professor at New York University (NYU) in the US.
Changes in the genetic code (mutations) that reduce TET2 function are found in 10 per cent of patients with acute myeloid leukemia (AML), 30 per cent of those with a form of pre-leukemia called myelodysplastic syndrome, and in nearly 50 per cent of patients with chronic myelomonocytic leukemia.
Such cancers cause anemia, infection risk, and bleeding as abnormal stem cells multiply in the bone marrow until they interfere with blood cell production, with the number of cases increasing as the population ages. Researchers studied the relationship between TET2 and cytosine, one of the four nucleic acid "letters" that comprise the DNA code in genes.
To determine the effect of mutations that reduce TET2 function in abnormal stem cells, the team genetically engineered mice such that the scientists could switch the TET2 gene on or off. They found that similar to the naturally occurring effects of TET2 mutations in mice or humans, using molecular biology techniques to turn off TET2 in mice caused abnormal stem cell behaviour.
These changes were reversed when TET2 expression was restored by a genetic trick.
Previous studies had shown that vitamin C could stimulate the activity of TET2 and its relatives TET1 and TET3.
Since only one of the two copies of the TET2 gene in each stem cell is usually affected in TET2-mutant blood diseases, researchers hypothesised that high doses of vitamin C, which can only be given intravenously, might reverse the effects of TET2 deficiency by turning up the action of the remaining functional gene.
They found that vitamin C did the same thing as restoring TET2 function genetically. By promoting DNA demethylation, high-dose vitamin C treatment induced stem cells to mature, and also suppressed the growth of leukemia cancer stem cells from human patients implanted in mice. "Interestingly, we also found that vitamin C treatment had an effect on leukemic stem cells that resembled damage to their DNA," said Luisa Cimmino, assistant professor at NYU Langone Health.
Researchers combined vitamin C with a PARP inhibitor, a drug type known to cause cancer cell death by blocking the repair of DNA damage. They found that the combination had an enhanced effect on leukemia stem cells, further shifting them from self-renewal back toward maturity and cell death.
The results also suggest that vitamin C might drive leukemic stem cells without TET2 mutations toward death, given that it turns up any TET2 activity normally in place, Cimmino said. The study was published in the journal Cell.
- PTI , New York

Tariff
Add Rate

News Archive

Inside The New Nation

Entertainment »

Race 3 inches towards Rs 200 cr mark


Salman Khan's film Race 3 is unstoppable. The film, which hit screens on June 15, is giving all sorts of reasons for the star cast to celebrate. The Remo D'Souza directorial had already crossed the benchmark of Rs 100 crore at the Indian box office. But interestingly, the Salman fever ...

Editorial »

Unfortunately government has no political leadership to restore peace in Chattogram Hill Tracts


THREE more activists of Parbatya Chattogram Janasanghati Samity (MN Larma) and United People's Democratic Front (Democratic) were shot dead at their homes in Rangamati and Khagrachhari districts between Friday and Sunday. Conflicts between different groups in Chattogram Hill Tracts have led to the death of at least 22 people in ...

Business & Economy »

Shibbir Mahmud, Chairman, Board of Directors of Islamic Finance and Investment Limited, presiding over its 236th meeting at its head office in the city recently. AZM Saleh, Managing Director, Rezakul Haider, Anis Salahuddin Ahmad, Vice-Chairmen, Anwar Hossain Chowdhury, EC Chairman, Md. Jahidur Rahman, Audit Committee Chairman, SM Bakhtiar Alam, Hossain Mahmud, Liaquat Hossain Moghul and KBM Moin Uddin Chisty, Directors of the company were also present.


International »

China-N Korea joint efforts to bring peace, stability in Korean peninsula, hopes Xi


Reuters, Beijing : Chinese President Xi Jinping told visiting North Korean leader Kim Jong Un on Wednesday that with the joint efforts of the two countries, the Korean peninsula will definitely be peaceful and stable, official news agency Xinhua said.Xi made the comments during a meeting at Beijing's Diaoyutai state guest ...

Football »

Putin missed Russia-Egypt match but 'happy' at win


AFP, Moscow :The Kremlin on Wednesday said Vladimir Putin did not watch Russia's surprise win over Egypt in the World Cup because he was on a plane but added that he reacted "very positively, like the whole of our country".  "Unfortunately, he did not watch the match itself. It so ...

City »

BNP Standing Committee Member Barrister Moudud Ahmed speaking at a prèss conference at the party central office in the city's Nayapalton on Wednesday in protest against his confinement by police in Noakhali.


Editorial »

Death of another prosecution witness : Too difficult to accept as an accident


NO sooner had the Eid vacation come to an end but another murder shocked us all. The decapitated body of Sumon Zahid, a witness in a war crimes case and also the son of martyred journalist Selina Parvin was found dead in the capital's Khilgaon the day before yesterday. There ...

Business & Economy »

A delegation headed by Farzana Chowdhury, CEO of Green Delta Insurance makes a courtesy call with Dr. M Khairul Hossain, the newly appointed Chairman of Security Exchange Commission recently. Additional Managing Director and Company Secretary Syed Moinuddin Ahmed and Deputy Managing Director Wafi S M Khan of the company were also present.


Football »

England beat Tunisia 2-1


AFP, Volgograd :Captain Harry Kane came to the rescue with two goals, the second a dramatic injury-time winner, as England began their World Cup Group G campaign with a stuttering 2-1 win over Tunisia on Monday.  Gareth Southgate's men almost paid a heavy price for missing a slew of first-half ...

Football »

Harry Kane : England's new prince


AFP, Volgograd :Harry Kane rose emphatically to the World Cup challenge in England's opening match against Tunisia, scoring a last-gasp winner to give Gareth Southgate's side lift-off in Russia.It was a remarkable World Cup debut for Kane, who bore the added pressure of the captain's armband and the weight of ...

Entertainment »

I`m indebted to J.P. Dutta for life : Pooja Bhatt


Actress-filmmaker Pooja Bhatt said she is indebted to veteran director J.P. Dutta for not only making her a part of 'Border' but also for encouraging her to never change. 'Border' on Wednesday completed 21 years of its release and Pooja took to Twitter to thank Dutta for casting her in ...

International »

US won`t be made a migrant camp


President Donald Trump vowed on Monday that the United States would not become a "migrant camp" as he faced mounting pressure to stop families being separated as a deterrent to illegal immigration."The United States will not be a migrant camp, and it will not be a refugee holding facility," Trump ...

City »

Pedestrians passing through a muddy road as the authority concerned does not repair the road for long time. The snap was taken from Bibir Bagicha area in the city's Jatrabari on Tuesday.


Editorial »

Save the flood victims and take adequate measures for post-flood rehabilitation


INCESSANT rainfall in the last few days has triggered floods in the country's East and South East districts. Thousands of people of Moulvibazar, Habiganj, Feni and Chattogram districts have been marooned as floodwater crawled to inundate their homestead and damage crops and livestock. The New Nation recently reported that Khowai, ...

Football »

A Mexico soccer fan celebrates her team victory against Germany after their group F match at the 2018 soccer World Cup in the Luzhniki Stadium in Moscow, Russia on Sunday.


 
Items that you save may be read at any time on your computer, iPad, iPhone or Android devices.
 
Are you new to our website? Do you have already an account at our website?
Create An Account Log in here
Email this news to a friend or like someone
Email:
Write a comment to this news