Home Today's Paper Most Popular Video Gallery Photo Gallery
Subscription Blog Signin Register
Logo
Monday, July 23, 2018 07:37:47 PM
Follow Us On: Facebook Twitter Twitter Twitter Twitter

Manipulation of mitochondrial network increases lifespan

photo by

By
10th-Nov-2017       
Comments
Share your thought
Post a comment »
Read all () »

Life Desk :
Lifespan and health may be promoted through manipulation of the mitochondrial network either by dietary restriction or by genetic manipulation that mimics it, according to recent research at the Harvard T.H. Chan School of Public Health.
Manipulation of Mitochondrial Network Increases Lifespan
The scientists used C. elegans (nematode worms), which live just two weeks and thus enable the study of aging in real time in the lab.
Mitochondrial networks inside cells typically toggle between fused and fragmented states. The researchers found that restricting the worms' diet, or mimicking dietary restriction through genetic manipulation of an energy-sensing protein called AMP-activated protein kinase (AMPK), maintained the mitochondrial networks in a fused or "youthful" state.
In addition, they found that these youthful networks increase lifespan by communicating with organelles called peroxisomes to modulate fat metabolism.
'Preserving mitochondrial network homeostasis during aging by co-inhibition of fusion and fission is sufficient itself to increase lifespan.'
Relationship between low energy conditions and healthy aging
"Low-energy conditions such as dietary restriction and intermittent fasting have previously been shown to promote healthy aging. Understanding why this is the case is a crucial step towards being able to harness the benefits therapeutically," said Heather Weir, lead author of the study, who conducted the research while at Harvard Chan School and is now a research associate at Astex Pharmaceuticals. "Our findings open up new avenues in the search for therapeutic strategies that will reduce our likelihood of developing age-related diseases as we get older."
"Although previous work has shown how intermittent fasting can slow aging, we are only beginning to understand the underlying biology," said William Mair, associate professor of genetics and complex diseases at Harvard Chan School and senior author of the study. "Our work shows how crucial the plasticity of mitochondria networks is for the benefits of fasting. If we lock mitochondria in one state, we completely block the effects of fasting or dietary restriction on longevity."
The study, published online October 26, 2017 in Cell Metabolism, sheds light on the basic biology involved in cells' declining ability to process energy over time, which leads to aging and age-related disease, and how interventions such as periods of fasting might promote healthy aging.
Mitochondria and aging
Mitochondria are the energy-producing structures in cells. They exist in networks that dynamically change shape according to energy demand. Their capacity to do so declines with age, but the impact this has on metabolism and cellular function was previously unclear. In this study, the researchers showed a causal link between dynamic changes in the shapes of mitochondrial networks and longevity.
Next steps for the researchers including testing the role mitochondrial networks have in the effect of fasting in mammals, and whether defects in mitochondrial flexibility might explain the association between obesity and increased risk for age-related diseases.
Source: Eurekalert

Tariff
Add Rate

News Archive

Inside The New Nation

Editorial »

Coal missing at Barapukuria


THE Barapukuria coal-fired power plant is going to shut down immediately for an indefinite period as its fuel mysteriously disappeared from a yard.  Two units of the plant, with the capacity of 125MW each, have already been turned off. The other unit, with a capacity of 275MW, was waiting for ...

Sports »

Tokyo christens futuristic 2020 Olympic mascots


AFP, Tokyo :Japanese organisers formally introduced their doe-eyed 2020 Olympic mascots to the world on Sunday, christening them with superhero names that could provide a tongue-twisting challenge to some.The blue-checked Olympic mascot was dubbed "Miraitowa" - combining the Japanese words for future and eternity, organisers said at an event in ...

Football »

Cruz Azul's Edgar Mendez eyes the ball during a national league soccer match against Puebla at the Azteca Stadium in Mexico City on Saturday.


City »

Anisul Islam Mahmud, Minister for Environment, Forest and Climate Change speaking as Chief Guest at a launching of book titled ' The Paris framework for climate change capacity building' at Jatiya Press Club yesterday.


Entertainment »

Why Urvashi has been dropped from heaven?


The stunning Urvashi Rautela always looks radiant in all her Instagram pictures. She makes our jaw drop with every single picture. But this time it would totally be unfair if we even try describing her latest picture in Abu Jani-Sandeep Khosla lehenga.  Urvashi looks so angelic, we wonder if she ...

Entertainment »

Bipasha as brand envoy of Natasha`s Irises


Sheikh Arif Bulbon :Ekushey Award winner noted actor, playwright and director Abul Hayat's two perfect daughters Bipasha Hayat and Natasha Hayat. Following her father’s footsteps on the screen Bipasha has already won the hearts of many viewers by virtue of her acting. But Natasha did not follow that step. Fashion ...

International »

UK to refuse Brexit bill without trade deal: Report


AFP, London :Britain will only pay its EU divorce bill if the bloc agrees the framework for a future trade deal, the new Brexit Secretary warned in an interview published Sunday.Dominic Raab, who replaced David Davis after he quit the role earlier this month in protest over the government's Brexit ...

Entertainment »

Dhadak Public Review: Ishaan Khatter, Janhvi Kapoor win hearts


The day is finally here and Ishaan Khatter - Janhvi Kapoor starrer Dhadak has hit the theatres. The film that marks the debut of late actress Sridevi's daughter opposite Shahid Kapoor's younger brother has won audiences heart. A remake of the Marathi blockbuster Sairat, Dhadak is helmed by director Shashank ...

Entertainment »

Ram Gopal Varma to make a biopic on Sanjay Dutt


Sanju has become one of the biggest hits of Bollywood. Directed by Rajkumar Hirani, Sanju gives us a glimpse of the controversial life of Sanjay Dutt and touches upon sensitive issues like his addiction to drugs, his difficulty in dealing with the passing away of his mother and the label ...

Sports »

A participant of the talent hunt programme of archerers in action at the Bir Shreshtha Nur Mohammad Stadium in Narail on Saturday. Bangladesh Archery Federation has arranged the programme, while City Group has sponsored the programme.


Sports »

Sloane Stephens of the United States, returns to opponent Madison Keys, also of the United States during an exhibition match at the International Hall of Fame's center court on Friday.


City »

Prime Minister Sheikh Hasina receiving letter of honour from Awami League (AL) General Secretary and also Road, Transport and Bridges Minister Obaidul Quader at a reception accorded to her organised by AL at Suhrawardy Udyan in the city on Saturday.


Editorial »

CHT people must be assured sense of participation: Fear of force doesn`t win people


THE lack of government's desire over holding elections to the regional council and the three District Councils in Chattogram Hill Tracts has long been depriving indigenous people of their right to have elected representatives in the local bodies. News media reported that for almost two decades, the District Councils have ...

International »

US presses China and Russia to enforce sanctions on N Korea


AP, United Nations : The United States on Friday welcomed the U.N. Security Council's united support for the fully verified denuclearization of North Korea and pressed China and Russia to strictly enforce U.N. sanctions to get Pyongyang to give up its nuclear weapons.U.S. Secretary of State Mike Pompeo accused North Korea ...

Editorial »

World must be united to ensure trial of the genocide against Rohingya people


ROHINGYA refugees reaching Bangladesh said violence, including torture, persists against them in Myanmar and the overall environment remains "menacing" for ethnic and religious minorities. UN human rights investigators carried out the Rohingya's plight after a five-day visit to the refugee camp of Kutupalong in Cox's Bazar where they interviewed new ...

 
Items that you save may be read at any time on your computer, iPad, iPhone or Android devices.
 
Are you new to our website? Do you have already an account at our website?
Create An Account Log in here
Email this news to a friend or like someone
Email:
Write a comment to this news