Home Today's Paper Most Popular Video Gallery Photo Gallery
Subscription Blog Signin Register
Logo
Wednesday, January 24, 2018 03:27:47 PM
Follow Us On: Facebook Twitter Twitter Twitter Twitter

Alcohol damages DNA, increases cancer risk

photo by

By
08th-Jan-2018       
Comments
Share your thought
Post a comment »
Read all () »

Life Desk  :
Alcohol consumption permanently damages the DNA in stem cells, which in turn increases the risk of developing cancer, a study led by an Indian-origin scientist warns.
Much previous research looking at the precise ways in which alcohol causes cancer has been done in cell cultures. However, in the new study, researchers used mice to show how alcohol exposure leads to permanent genetic damage.
Scientists at the MRC Laboratory of Molecular Biology at the University of Cambridge in the UK gave diluted alcohol, chemically known as ethanol, to mice. They then used chromosome analysis and DNA sequencing to examine the genetic damage caused by acetaldehyde, a harmful chemical produced when the body processes alcohol. The researchers found that acetaldehyde can break and damage DNA within blood stem cells leading to rearranged chromosomes and permanently altering the DNA sequences within these cells.
"Some cancers develop due to DNA damage in stem cells," said Professor Ketan Patel from the MRC Laboratory of Molecular Biology. "While some damage occurs by chance, our findings suggest that drinking alcohol can increase the risk of this damage," said Patel, lead author of the study published in the journal Nature.
It is important to understand how the DNA blueprint within stem cells is damaged because when healthy stem cells become faulty, they can give rise to cancer, researchers said. The new findings help us to understand how drinking alcohol increases the risk of developing seven types of cancer including common types like breast and bowel, they said.
The study also examined how the body tries to protect itself against damage caused by alcohol. The first line of defence is a family of enzymes called aldehyde dehydrogenases (ALDH). These enzymes break down harmful acetaldehyde into acetate, which our cells can use as a source of energy. Worldwide, millions of people, particularly those from South East Asia, either lack these enzymes or carry faulty versions of them, researchers said. When they drink, acetaldehyde builds up which causes a flushed complexion, and also leads to them feeling unwell, they said.
In the study, when mice lacking the critical ALDH enzyme - ALDH2 - were given alcohol, it resulted in four times as much DNA damage in their cells compared to mice with the fully functioning ALDH2 enzyme. The second line of defence used by cells is a variety of DNA repair systems which, most of the time, allow them to fix and reverse different types of DNA damage.
However, they do not always work and some people carry mutations which mean their cells are not able to carry out these repairs effectively. "Our study highlights that not being able to process alcohol effectively can lead to an even higher risk of alcohol-related DNA damage and therefore certain cancers," Patel said. "But it is important to remember that alcohol clearance and DNA repair systems are not perfect and alcohol can still cause cancer in different ways, even in people whose defence mechanisms are intact," he added.
- PTI, London

Tariff
Add Rate

News Archive

Inside The New Nation

Editorial »

EC must upgrade database urgently


THE database of Election Commission (EC) containing elaborate information of about 10.5 crore voters may crash at any time  as they have not upgraded the hardware and software, including the automated fingerprint identification system, in due time. Besides, storage capacity of Oracle Exadata system has also expired which has increased ...

International »

Abbas seeks EU recognition to State of Palestine


AFP, Brussels :Palestinian leader Mahmud Abbas on Monday urged the EU to "swiftly" grant official recognition to the state of Palestine as he sought support in Brussels amid a bitter row with Washington over the US plan to move its embassy to Jerusalem.Abbas told EU diplomatic chief Federica Mogherini that ...

Business & Economy »

L'Oreal hijab model pulls out of campaign after backlash over tweets


Evening Standard :A beauty blogger who was the first ever hijab-wearing model to front a mainstream haircare ad has pulled out of a campaign with L'Oreal after a backlash over tweets she wrote in 2014. Amena Khan wrote on Instagram that she had decided to step down from the campaign ...

Cricket »

Tamim joins 6000 runs ODI club


Southpaw opener Tamim Iqbal reached another milestone as he joined 6000 runs ODI Club during the 5th ODI of the triangular series against Zimbabwe at Sher-e-Bangla National Cricket Stadium art Mirpur on Tuesday.The dashing opener Tamim, who hit his third consecutive fifties in this series so far, needed 66 runs ...

Entertainment »

Fahmee to debut in big screen


Sheikh Arif Bulbon :Though she has been acting in small screen for many days but Fahmida Sharmeen Fahmee had a dream to work in the big screen. At last, her dream comes into true. Finally she has been selected to cast in role of Farzana in Mizanur Rahman Labu’s movie ...

Entertainment »

SRK gets special honour at WEF


Bollywood superstar Shah Rukh Khan was at his wittiest best in Davos on Monday when he asked actress Cate Blanchett for a selfie publicly and immediately quipped that it may leave his children embarrassed, sending the audience into peals of laughter. Khan received the 24th Crystal Award on Monday at ...

City »

BNP Chairperson Begum Khaleda Zia appeared before the special court on Alia Madrasha premises in the city's Bakshibazar on Tuesday on two cases filed by Anti-Corruption Commission.


Editorial »

Banking sector is doomed, merger or no merger


FINANCE Minister AMA Muhith has recommended Bangladesh Bank to start merger of problem banks, but experts fear that such a move would not stop the rot the country's banking sector is facing. On December 28, Muhith wrote a letter to BB Governor Fazle Kabir pointing out that it was the ...

Sports »

Romania's Simona Halep celebrates after defeating Japan's Naomi Osaka during their fourth round match at the Australian Open tennis championships in Melbourne, Australia on Monday.


International »

Turkey in new assault on Kurdish militia on Syria


AFP  :Turkey on Monday shelled Kurdish militia targets in Syria and claimed progress in a cross-border offensive that has stoked concern among its allies and neighbours.The Turkish military on Saturday launched operation "Olive Branch", its second major incursion into Syrian territory during the seven-year civil war.The operation, where Turkish war ...

City »

BNP Standing Committee Member Gayeshwar Chandra Roy, among others, at a protest rally organised by Akhtar Hossain Mukti Parishad at the Jatiya Press Club on Monday demanding release of all BNP leaders including Organizing Secretary of Dhaka Mahanagar Uttar Akhtar Hossain.


Entertainment »

Yami Gautam applauds India’s win at Blind Cricket World Cup 2018


Bollywood actress Yami Gautam took to Twitter to applaud the victory of India at the Blind Cricket World Cup 2018. India retained Blind Cricket World Cup title after beating Pakistan by two wickets in a thrilling final played at the Sharjah Cricket Stadium in UAE on Saturday. India had previously ...

Entertainment »

Razzak’s birthday today


Entertainment Report :If he would alive today he will turn into 77. He died on August 21 of 2017. His sudden demise made a gap in the field industry. He was basically a guardian in film arena. Today is birthday of legendary film actor Razzak. Younger son of Razzak, Khalid ...

Editorial »

Migrant workers` early death should worry our govt


A NATIONAL daily reported that at least 3,480 Bangladeshi workers died abroad in 2017, mostly due to stroke or heart attack. Unbearable physical and mental stress, workload, malnutrition, ill health care, thin sleep and rest time, and unhygienic living decrease the life expectancy of the Bangladeshi expatriates workers working in ...

Cricket »

Star all-rounder Shakib in Marquee' player list for IPL Auction


World no. one all-rounder rounder Shakib Al Hasan booked his place in the IPL auctions as a 'Marquee' player list with a base price of RS 2 Crore which is the base price for the all 16 elite players in the Marquee Players' list.The star all-rounder Shakib was placed alongside ...

 
Items that you save may be read at any time on your computer, iPad, iPhone or Android devices.
 
Are you new to our website? Do you have already an account at our website?
Create An Account Log in here
Email this news to a friend or like someone
Email:
Write a comment to this news