Home Today's Paper Most Popular Video Gallery Photo Gallery
Subscription Blog Signin Register
Logo
Thursday, October 18, 2018 02:21:37 PM
Follow Us On: Facebook Twitter Twitter Twitter Twitter

Alcohol damages DNA, increases cancer risk

photo by

By
08th-Jan-2018       
Comments
Share your thought
Post a comment »
Read all () »

Life Desk  :
Alcohol consumption permanently damages the DNA in stem cells, which in turn increases the risk of developing cancer, a study led by an Indian-origin scientist warns.
Much previous research looking at the precise ways in which alcohol causes cancer has been done in cell cultures. However, in the new study, researchers used mice to show how alcohol exposure leads to permanent genetic damage.
Scientists at the MRC Laboratory of Molecular Biology at the University of Cambridge in the UK gave diluted alcohol, chemically known as ethanol, to mice. They then used chromosome analysis and DNA sequencing to examine the genetic damage caused by acetaldehyde, a harmful chemical produced when the body processes alcohol. The researchers found that acetaldehyde can break and damage DNA within blood stem cells leading to rearranged chromosomes and permanently altering the DNA sequences within these cells.
"Some cancers develop due to DNA damage in stem cells," said Professor Ketan Patel from the MRC Laboratory of Molecular Biology. "While some damage occurs by chance, our findings suggest that drinking alcohol can increase the risk of this damage," said Patel, lead author of the study published in the journal Nature.
It is important to understand how the DNA blueprint within stem cells is damaged because when healthy stem cells become faulty, they can give rise to cancer, researchers said. The new findings help us to understand how drinking alcohol increases the risk of developing seven types of cancer including common types like breast and bowel, they said.
The study also examined how the body tries to protect itself against damage caused by alcohol. The first line of defence is a family of enzymes called aldehyde dehydrogenases (ALDH). These enzymes break down harmful acetaldehyde into acetate, which our cells can use as a source of energy. Worldwide, millions of people, particularly those from South East Asia, either lack these enzymes or carry faulty versions of them, researchers said. When they drink, acetaldehyde builds up which causes a flushed complexion, and also leads to them feeling unwell, they said.
In the study, when mice lacking the critical ALDH enzyme - ALDH2 - were given alcohol, it resulted in four times as much DNA damage in their cells compared to mice with the fully functioning ALDH2 enzyme. The second line of defence used by cells is a variety of DNA repair systems which, most of the time, allow them to fix and reverse different types of DNA damage.
However, they do not always work and some people carry mutations which mean their cells are not able to carry out these repairs effectively. "Our study highlights that not being able to process alcohol effectively can lead to an even higher risk of alcohol-related DNA damage and therefore certain cancers," Patel said. "But it is important to remember that alcohol clearance and DNA repair systems are not perfect and alcohol can still cause cancer in different ways, even in people whose defence mechanisms are intact," he added.
- PTI, London

Tariff
Add Rate

News Archive

Inside The New Nation

Football »

Groeneveld scores as Netherlands draw 1-1 with Belgium


AP, Brussels :Arnaut Groeneveld celebrated his first start for the Netherlands by scoring a first-half equalizer Tuesday as the Dutch drew 1-1 with neighbor Belgium.The 21-year-old midfielder who plays for Belgium's Club Brugge rounded off a flowing Dutch move in the 27th minute, controlling the ball with his left foot ...

Football »

Brazil's Miranda silences Argentina with last-gasp winner


AFP, Jeddah :Brazil snatched a dramatic 1-0 win over Argentina with an injury-time header from Miranda in their friendly match in front of a sell-out crowd in Jeddah, Saudi Arabia on Tuesday.The Inter Milan centre-back was left all alone to thump in a 93rd-minute effort from Neymar's corner when the ...

Editorial »

EC failed to prove its neutrality


WHEN the country is facing a political uncertainty over the polls-time government coupled with the dissatisfactory role of the Election Commission, Chief Election Commissioner (CEC) KM Nurul Huda on Tuesday said the Election Commission will do everything necessary to hold free and fair elections. Its sound good but the hollowness ...

International »

Irish author Anna Burns wins 2018 Man Booker Prize


Reuters, London :"Milkman" by writer Anna Burns scooped the 2018 Man Booker Prize on Tuesday, with the Northern Irish writer winning the literary award for her third full-length novel.Set in an unnamed city during the bloody "Troubles" of Northern Ireland, the "Milkman" tells the coming-of-age story of a young girl's ...

City »

Bangladesh Federal Union of Journalists (BFUJ) leaders covering their months with blackclothes, demanding amendment of 9 Sections of the Digital Security Act as black law in front of Jatiya Press Club on Wednesday.


Entertainment »

Affri Selina in three films


Sheikh Arif Bulbon :Affri Selina is establishing her position in media slowly day by day. Earlier, she had interest to perform as a model in showbiz but later she became interested to acting. So, now she has full concentration to acting. Yesterday she took part in shooting of a music ...

Cricket »

ICC WC Trophy to arrive in Bangladesh today


ICC World Cup (WC) Trophy will arrive in Bangladesh today as part of its worldwide 'Trophy Tour' ahead of ICC Cricket World Cup 2019 scheduled to be held in England.The trophy will be visiting Bangladesh's three cities - Dhaka, Sylhet and Chattogram over five days period. It will be displayed ...

Sports »

In this photo provided by the OIS/IOC, Russia's Mariya Kochanova competes in the Women's High Jump at the Athletics Field during the Youth Olympic Games in Buenos Aires, Argentina on Monday.


International »

Maldives court rejects Yameen's secret witnesses


AFP, Colombo :The Maldives' top court rejected on Tuesday three "secret" witnesses offered by President Abdulla Yameen in his petition to have his September election defeat annulled, in what is likely a major blow to his case.The refusal came as the Supreme Court concluded its hearings, which also saw Yameen ...

Business & Economy »

Microsoft co-founder Paul Allen dies


AFP, San Francisco :Paul Allen, who founded Microsoft with Bill Gates in the 1970s and later went on to become an investor, philanthropist and sports team owner, died Monday after his latest battle with cancer at age 65."My brother was a remarkable individual on every level. While most knew Paul ...

Entertainment »

Being married to Tom Crusie kept me from being sexually harassed: Nicole Kidman


Nicole Kidman says she had married Tom Cruise for love and tying the knot with the actor inadvertently shielded her from being sexually harassed in Hollywood. The 51-year-old actor, who was married to Cruise for 11 years, said after their divorce in 2001, she had to start looking after herself. ...

Editorial »

Question paper leakage continues: Incompetence is everywhere


QUESTION paper leaks have become epidemic before all public exams, university admission tests, and job recruitment tests during the current administration allegedly by some students and unscrupulous teachers along with office staffs. Detectives in recent times busted dens of criminals involved in the question leakage but the unholy nexus between ...

Football »

US headed to Women's World Cup with 6-0 win over Jamaica


AP, Frisco :The U.S. women's national team breezed through CONCACAF qualifying to secure a spot in the World Cup next year in France.The Americans still have to face Canada."Just because we qualified for the World Cup doesn't mean we're going to take our foot off the gas," Alex Morgan said. ...

Cricket »

India ready to unleash 'fearless' Shaw, Pant on Australia


"Fearless" young batting stars Prithvi Shaw and Rishabh Pant will be India's special weapons during their upcoming tour of Australia, according to captain Virat Kohli.Hailing the roles of 18-year-old Shaw and 21-year-old Pant in the two-Test victory over the West Indies, Kohli said they had been given free rein to ...

International »

Saudi Arabia warns against any sanctions over missing Khashoggi case


Reuters, Washington :Saudi Arabia on Sunday warned against threats to punish it over last week's disappearance of journalist Jamal Khashoggi, as European leaders piled on pressure and two more US executives scrapped plans to attend a Saudi investor conference.Khashoggi, a US resident and Washington Post columnist critical of Riyadh's policies, ...

 
Items that you save may be read at any time on your computer, iPad, iPhone or Android devices.
 
Are you new to our website? Do you have already an account at our website?
Create An Account Log in here
Email this news to a friend or like someone
Email:
Write a comment to this news