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Women who do night shifts may be at risk of cancer

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15th-Jan-2018       
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Life Desk :
Long-term night shift work in women was associated with risk for nearly a dozen types of cancer. Breast, skin, and gastrointestinal cancer was associated with night shift work in women. Nurses, compared to other professionals are at the highest risk of breast cancer.
Night shift work was associated with women having an increased risk of breast, skin, and gastrointestinal cancer, according to a review of various studies.
Xuelei Ma and colleagues performed a meta-analysis using data from 61 articles comprising 114,628 cancer cases and 3,909,152 participants from North America, Europe, Australia, and Asia.
'For every 5 years of night-shift work, the risk of breast cancer increases by 3.3%'
Breast cancer is the most diagnosed cancer among women worldwide, most previous meta-analyses have focused on understanding the association between female night shift workers and breast cancer risk, but the conclusions have been inconsistent. The team analyzed whether long-term night shift work in women was associated with risk for nearly a dozen types of cancer.
The studies were analyzed for an association between long-term night shift work and risk of 11 types of cancer. A further analysis was conducted, which looked specifically at long-term night shift work and risk of six types of cancer among female nurses.
After stratifying the participants by location, Ma found that an increased risk of breast cancer was only found among female night shift workers in North America and Europe.
"We were surprised to see the association between night shift work and breast cancer risk only among women in North America and Europe," said Ma. "It is possible that women in these locations have higher sex hormone levels, which have been positively associated with hormone-related cancers such as breast cancer."
Among female nurses alone, those who worked the night shift had an increased risk of breast (58 percent), gastrointestinal (35 percent), and lung cancer (28 percent) compared with those that did not work night shifts. Of all the occupations analyzed, nurses had the highest risk of developing breast cancer if they worked the night shift.
"Nurses that worked the night shift were of a medical background and may have been more likely to undergo screening examinations," noted Ma. "Another possible explanation for the increased cancer risk in this population may relate to the job requirements of night shift nursing, such as more intensive shifts."
The research team also performed a dose-response meta-analysis among breast cancer studies that involved three or more levels of exposure. They found that the risk of breast cancer increased by 3.3 percent for every five years of night shift work.
"By systematically integrating a multitude of previous data, we found that night shift work was positively associated with several common cancers in women," said Ma. "The results of this research suggest the need for health protection programs for long-term female night shift workers.
"Our study indicates that night shift work serves as a risk factor for common cancers in women," said Ma. "These results might help establish and implement effective measures to protect female night shifters. Long-term night shift workers should have regular physical examinations and cancer screenings.
"Given the expanding prevalence of shift work worldwide and the heavy public burden of cancers, we initiated this study to draw public attention to this issue so that more large cohort studies will be conducted to confirm these associations," he added.
Study Limitations: A limitation of this work is a lack of consistency between studies regarding the definition of "long-term" night shift work, with definitions including "working during the night" and "working at least three nights per month." Additional limitations include significant between-study heterogeneity and publication bias.

Source: Medindia

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