Home Today's Paper Most Popular Video Gallery Photo Gallery
Subscription Blog Signin Register
Logo
Monday, June 18, 2018 09:44:38 PM
Follow Us On: Facebook Twitter Twitter Twitter Twitter

Long use of caffeine aggravates Alzheimer

photo by

By
08th-Jun-2018       
Comments
Share your thought
Post a comment »
Read all () »

Adeline Dorcas :
Alzheimer's disease is associated with memory-related problems. It is characterized by neuropsychiatric symptoms found in the early stages. Long-term use of caffeine is found to alter these neuropsychiatric symptoms in patients with Alzheimer's disease.
The neuropsychiatric symptoms include behavioral and psychological symptoms of dementia (BPSD), anxiety, apathy, hallucinations, paranoid and sundowning.
'Long-term use of caffeine may alter the neuropsychiatric symptoms, increase neophobia and anxiety-related behaviors in patients with Alzheimer's disease.'
Coffee or caffeine has recently been suggested as a strategy to prevent dementia, both in patients with Alzheimer's disease and in normal aging processes, due to its action in blocking molecules - adenosine receptors - which may cause dysfunctions and diseases in old age. However, there is some evidence that once the cognitive but also the NPS symptoms are developed, caffeine may exert opposite effects.
To address these issues, the study was conducted with normal aging mice and familial Alzheimer's models. "The mice develop Alzheimer's disease in a very close manner to the human patients with the early-onset form of the disease. They not only exhibit the typical cognitive problems but also a number of BPSD-like symptoms, so it is a valuable model to address whether the benefits of caffeine will be able to compensate its putative negative effects", explains Raquel Baeta-Corral, first author of the research.
"We had previously demonstrated the importance of the adenosine A1 receptor as the cause of some of caffeine's adverse effects. Now, we simulated a long oral treatment with a very low dose of caffeine (0.3 mg/mL) equivalent to three cups for a human coffee-drinker to answer a question which is relevant for patients with Alzheimer's, but also for the aging population in general, and that in humans would take years to be solved since we should wait until the patients were aged' - explains Dr Björn Johansson, researcher and physician at the Karolinska University Hospital. The research was conducted from the onset of the disease up to more advanced stages, as well as in healthy age-matched mice.
The results indicate that caffeine alters the behavior of healthy mice and worsens the neuropsychiatric symptoms of mice with Alzheimer's disease. The researchers discovered significant effects in the majority of variables studies, especially in relation to neophobia, a fear of everything new, anxiety-related behaviors, and emotional and cognitive flexibility.
In mice with Alzheimer's disease, the increase in neophobia and anxiety-related behaviors exacerbates their BPSD-like profile. Learning and memory, strongly influenced by anxiety, got little benefit from caffeine.
"Our observations of adverse caffeine effects in an Alzheimer's disease model together with previous clinical observations suggest that an exacerbation of BPSD-like symptoms may partly interfere with the beneficial cognitive effects of caffeine. These results are relevant when coffee-derived new potential treatments for dementia are to be devised and tested", says Dr. Lydia Giménez-Llort, researcher from the INc-UAB Department of Psychiatry and Legal Medicine and lead researcher of the project.
The results of the study form part of the Ph.D. thesis of Raquel Baeta-Corral, first author of the article, and are the product of a research led by Lydia Giménez-Llort, Director of the Medical Psychology Unit, Department of Psychiatry and Legal Medicine and researcher at the UAB Institute of Neuroscience, together with Dr Björn Johansson, Researcher at the Department of Molecular Medicine and Surgery, Karolinska Institutet and the Department of Geriatrics, Karolinska University Hospital, Sweden, under the framework of the Health Research Fund project of the Institute of Health Carlos III*.
Source: Eurekalert

Tariff
Add Rate

News Archive

Inside The New Nation

Editorial »

Eid Mubarak


EID UL FITR is an important religious event celebrated by Muslims worldwide that marks the end of Ramadan, the Islamic holy month of fasting (sawm). The Eid (Muslim religious festival) is the first and only day in the month of Shawal during which Muslims are not permitted to fast. The ...

Cricket »

History-making Afghanistan get baptism of fire in Test cricket


AFP, Bangalore :Afghanistan were handed a bruising introduction to Test cricket by India on Thursday as they capped their astonishing rise from war and refugee camps to joining the sport's elite.Afghan skipper Asghar Stanikzai called it a "very proud moment" as he strode onto the field at Bangalore's M. Chinnaswamy ...

Football »

Orlando City midfielder Josue Colman kicks the ball away from Montreal Impact defender Rod Fanni during the second half of an MLS soccer match on Wednesday in Montreal.


Football »

German Chancellor Angela Merkel (center) and the former German national soccer team player and integration commissioner of the German soccer association, Cacau (right) attend a women soccer training session at a soccer club in Berlin, Germany on Wednesday.


International »

World can `sleep well` after North Korea summit: Trump


A jubilant-sounding President Donald Trump declared Wednesday that his "deal" with Kim Jong Un has ended the North Korean nuclear threat, as his top diplomat said he hoped to see "major disarmament" of the country by 2020.Despite the lack of detail, or binding terms in the joint statement agreed with ...

International »

UN rights office calls for int’l probe in Kashmir


AP, Geneva :The U.N. human rights chief called Thursday for an independent, international investigation into reports of rights violations in the disputed region of Kashmir, laying blame for civilian deaths and injuries on the actions of both India and Pakistan.In its first report on the region, the office of Zeid ...

City »

Air Chief adorned with Air Marshal rank badge


A ceremony marking the adorning of rank badge of new Chief of Air Staff Air Marshal Masihuzzaman Serniabat was held at the Prime Minister's Office (PMO) on Thursday.In the presence of Prime Minister Sheikh Hasina, Chief of Army Staff General Abu Belal Mohammad Shafiul Huq and Chief of Naval Staff ...

Entertainment »

Sylvester Stallone under probe for sexual assault


Los Angeles prosecutors said on Wednesday that their sex crimes team was reviewing a case against Rocky actor Sylvester Stallone. Los Angeles District Attorney's office spokesman Greg Risling did not give details but said the case was presented by police in the California beach city of Santa Monica.Representatives for Stallone, ...

Editorial »

Pay the workers immediately, let them celebrate the Eid


NEWS media reported that nearly 40 percent of the garment factories, most of which are small and not members of any trade bodies like the BGMEA or the BKMEA, are yet to pay the workers' salaries or festival bonus although Eid-ul-Fitr is knocking at the door. Most of the 4.4 ...

International »

N Korean state media hails Kim-Trump summit success


Reuters, Seoul  :US President Donald Trump and North Korean leader Kim Jong Un were splashed across North Korea's official party newspaper on Wednesday as state media hailed Tuesday's historic summit between the two men.The North's state media framed Tuesday's summit as a win for Pyongyang as it listed concessions made ...

Entertainment »

Secrets of Punam Priyam`s success


Entertainment Report :Punam Priyam is a popular media personality in Bangladesh. She is an anchor, producer and writer. In an interview with The New Nation, she has shared her life story and her views on different professional and personal issues. Details below:1. In our male dominated society men are still ...

Cricket »

Rahane says 'ruthless' India will not take Afghans lightly


AFP, Bangalore :Top-ranked India will be "ruthless" and not take Afghanistan lightly when they make their Test debut in Bangalore, skipper Ajinkya Rahane said Wednesday.It will be a historic moment for Asghar Stanikzai's team when they step out on Thursday for their maiden five-day outing against the world's number one ...

City »

Railway Minister Majibul Huq visited Kamalapur Railway Station in the city on Wednesday to witness the Eid journey of home-bound passengers.


Editorial »

Take urgent steps to prevent further landslides in hill region


AT least 11 people have been killed in separate incidents of landslides triggered by heavy rainfall in Rangamati and Cox's Bazar. Among the deceased, 10 were killed in Naniarchar upazila of Rangamati and one in Maheshkhali upazila of Cox's Bazar, as per a local daily report.In Naniarchar, landslides in Boro ...

Entertainment »

Chitrangda Singh wears the producer's hat!


Recently, 'Soorma' trailer starring Diljit Dosanjh and Taapsee Pannu in lead roles was released. While actress Chitrangda Singh who is been staying away from onscreen for a while has now overtaken the role of a producer for the movie, 'Soorma'. After Anushka Sharma and Priyanka Chopra trying their hands as ...

 
Items that you save may be read at any time on your computer, iPad, iPhone or Android devices.
 
Are you new to our website? Do you have already an account at our website?
Create An Account Log in here
Email this news to a friend or like someone
Email:
Write a comment to this news