Home Today's Paper Most Popular Video Gallery Photo Gallery
Subscription Blog Signin Register
Sunday, August 18, 2019 02:13:07 PM
Follow Us On: Facebook Twitter Twitter Twitter Twitter

Kidneys grown in rats could pave way for human transplant options

photo by AP photo

Scientists said Wednesday they have successfully used mice stem cells to grow kidneys in rat embryos, using a technique that could one day help grow human kidneys for transplant

Share your thought
Post a comment »
Read all () »

AFP, Tokyo :
 Scientists said Wednesday they have successfully used mice stem cells to grow kidneys in rat embryos, using a technique that could one day help grow human kidneys for transplant.
But the researchers cautioned that their success was only a first step and that "serious technical barriers and complex ethical issues" remain before the process could be used for human organs.
The technique has previously been used to grow mice-derived pancreases in rats, but the new study is the first evidence that it could one day provide a solution to the massive shortage of donor kidneys for people with renal disease.
The research, published Wednesday in the Nature Communications journal, began with the development of a suitable "host" in which the kidneys could be grown.
The researchers collected rat embryo structures that had been genetically modified so they would not develop kidneys on their own.
The embryos were then injected with pluripotent stem cells from mice and implanted into rat wombs so they could be carried to term.
Pluripotent stem cells are a kind of "master" cell that can develop into any of the cells and tissue that make up the body.
The researchers found that the mice stem cells produced apparently functional kidneys in the rats. But the same did not hold when rat stem cells were injected into similarly modified mice embryos.
"Rat stem cells did not readily differentiate into the two main types of
cells needed for kidney formation," said Masumi Hirabayashi, an associate
professor at Japan's National Institute for Physiological Sciences, who
supervised the study.
Conversely, "mouse stem cells efficiently differentiated… forming the basic structures of a kidney," he told AFP.
The reason for the difference is still not entirely clear, but the researchers believe "environmental cues" inside the mice are likely to blame, rather than the stem cells or technique.
But even in the rat embryos, the technique was not without problems.
While the rats developed apparently functional kidneys, including with proper connections to the ureter - tubes that link the kidneys to the bladder - they died shortly after birth because they did not suckle properly.
Removing the genes that allow kidneys to develop in utero appears to have also removed their sense of smell, so the newborns failed to detect milk and died.
Their short lives meant limited testing could be done on their kidney function, but Hirabayashi said the organs appeared functional "based on anatomical observations."
There are other concerns: growing a kidney in a host from another species could lead to "contamination" of the organ with cells from the host.
And the process of growing human organs in animals poses an ethical
conundrum because human stem cells could develop into brain or reproductive
organ cells in the host.
"The main ethical concerns are the risk of consciousness and/or gamete (reproductive cell) production," said Hirabayashi. "There are serious technical barriers and complex ethical issues that must be discussed and solved before producing human organs in animals," he added.
In the short-term, additional research is likely to focus on ways to genetically modify host rats without lethal side effects.
If successful, researchers will then want to run more tests on the stem cell-derived kidneys, and try to transplant them from the hosts to other animals.
Eventually, tests could involve trying to grow human organs.
Pigs are usually considered the best hosts for human organ regeneration, but pig embryos only develop for 16 weeks, unlike the 40 weeks that human babies grow, meaning the species might not be suitable for growing organs in embryos.
Cattle, with a 40-week gestation, could be another option.
Hirabayashi said he was hopeful he would see human organs grown in animal hosts in his lifetime.
"I don't know exactly the end of my lifetime - tomorrow? Thirty years? But I very much expect to hear news regarding the practical application of animal-hosted organs."

Add Rate

News Archive

Inside The New Nation

Editorial »

Jugglery of growth figures failed to create jobs

BANGLADESH'S economic growth though mesmerising, it has been proved over the past decade that jobs could not be created proportionately for the youths keeping adjustment with the growth. Besides, female participation in the labour force shrank in the last nine years, especially in rural areas. As a result employment elasticity, ...

Cricket »

Mashrafe seeks two months to ponder about his retirement

The Bangladesh Cricket Board (BCB) has shelved the idea of arranging a one-off ODI against Zimbabwe to give Mashrafe Bin Mortaza a grand farewell after the ODI captain asked the board to give him two months to think about his future.The decision to cancel the plan came after BCB president ...

Football »

Guardiola backs Sterling to reach 30-goal mark

AFP, Manchester :Pep Guardiola wants to see the on-form Raheem Sterling break the 30-goal barrier for the first time in his career this season, but will only judge the England forward on his overall contribution to the Manchester City team.Sterling has started the new campaign in prolific form, scoring in ...

City »

Bangabandu Sangskritik Jote paid tributes to Poet Shamsur Rahman by placing floral wreaths at his grave in the city's Banani on Saturday marking the 13th death anniversary of the poet.

International »

Hundreds defy restrictions, join protests in Kashmir

AP, New Delhi :Hundreds of people protested an unprecedented security crackdown and clashed with police Friday in Indian-controlled Kashmir, as India's government said it was constantly reviewing the situation in the disputed region and the restrictions there will be removed over the next few days.The U.N. Security Council met on ...

International »

Discussions on Afghan peace deal go ‘very well’, says Trump's spokesman

The White House says President Donald Trump's talks with his national security advisers to discuss Afghan peace talks went "very well" and that negotiations with the Taliban "are proceeding."Officials on August 16 said Trump was meeting with his top advisers to review negotiations with the extremist group about a possible ...

Entertainment »

Kona finally admits her secret marriage

Entertainment Desk :Popular singer Dilshad Nahar Kona revealed  on Thursday  that she had tied the knot with the person she loved, on April 21 of this year. Her husband, Golam Md Iftekhar, is a businessman, and has been in a relationship with Kona for seven years.Kona was heard saying to ...

Editorial »

Clashes among groups of govt followers on national mourning day

NEWSPAPERS reported that at least 22 people, including former Awami League lawmaker of Nilphamari-3 and upazila unit AL vice-president Golam Mustafa, were injured in a clash between two rival groups of the party in Jaldhaka of Nilphamari on Thursday. The clash took place when the groups hosted separate programmes to ...

City »

China-Bangla Friendship Association (CBFA) led by its President Dr Monouar Hasnat Khan and General Secretary Dr S.M Shahidul Islam placing wreaths at the Memorial Plaque of Father of the Nation Bangabandhu Sheikh Mujibur Rahman at 32 , Dhanmondi in the city on Thursday marking National Mourning Day .


Cricket »

England 258 all out in second Ashes Test

AFP, London :England were dismissed for 258 by Australia in the second Ashes Test at Lord's on Thursday.Only opener Rory Burns (53) and wicketkeeper Jonny Bairstow, last man out for 52, passed fifty after England were sent into bat by Australia captain Tim Paine following a total washout of Wednesday's ...

International »

Malaysia to question Zakir Naik for comments against Malaysian Hindus

Reuters, Kuala Lumpur :Malaysian authorities will summon controversial Islamic preacher Zakir Naik for questioning after he allegedly made racially sensitive remarks in the multi-ethnic nation, the government said on Thursday.The move comes after several ministers demanded Naik's expulsion on Wednesday after he said Hindus in Malaysia had "100 times more ...

Editorial »

Destroying biodiversity and its possible dangerous impact on human existence

BIODIVERSITY in Moulvibazar's Lathitila has been facing serious threat as settlers continue clearing forest areas for fruit cultivation and fish farming. According to newspaper reports, the vegetation at 5631.4 acres of land covered with hillocks is under continuous danger. Though only 30 landless families were allowed to settle inside the ...

Cricket »

BCB to discuss with Mashrafe about his retirement plan

The Bangladesh Cricket Board (BCB) will talk to Mashrafe Bin Mortaza within couple of days to know his retirement plan as the board has a plan to give the ODI captain a grand farewell.On multiple occasions, Mashrafe said he has not many cricket ahead, but he actually did not reveal ...

International »

Saudi woman activist rejects release deal tied to denying torture

Reuters, Riyadh :Prominent Saudi women's rights activist Loujain al-Hathloul has rejected a proposal to secure her release from prison in exchange for a video statement denying reports she was tortured in custody, her family said on Tuesday.Hathloul, along with at least a dozen other women's rights activists, were arrested over ...

International »

Pelosi vows to thwart US-UK trade deal if Brexit risks Irish peace

The top Democrat in the US Congress warned Wednesday that lawmakers would block a trade pact with Britain if its exit from the EU undermines Northern Ireland's peace accord.President Donald Trump and senior advisors to Britain's new Prime Minister Boris Johnson have spoken of fast-tracking a trade deal once Brexit ...

Items that you save may be read at any time on your computer, iPad, iPhone or Android devices.
Are you new to our website? Do you have already an account at our website?
Create An Account Log in here
Email this news to a friend or like someone
Write a comment to this news