Home Today's Paper Most Popular Video Gallery Photo Gallery
Subscription Blog Signin Register
Logo
Friday, February 22, 2019 03:15:51 AM
Follow Us On: Facebook Twitter Twitter Twitter Twitter
BREAKING NEWS:

Kidneys grown in rats could pave way for human transplant options

photo by AP photo

Scientists said Wednesday they have successfully used mice stem cells to grow kidneys in rat embryos, using a technique that could one day help grow human kidneys for transplant

By
07th-Feb-2019       
Comments
Share your thought
Post a comment »
Read all () »

AFP, Tokyo :
 Scientists said Wednesday they have successfully used mice stem cells to grow kidneys in rat embryos, using a technique that could one day help grow human kidneys for transplant.
But the researchers cautioned that their success was only a first step and that "serious technical barriers and complex ethical issues" remain before the process could be used for human organs.
The technique has previously been used to grow mice-derived pancreases in rats, but the new study is the first evidence that it could one day provide a solution to the massive shortage of donor kidneys for people with renal disease.
The research, published Wednesday in the Nature Communications journal, began with the development of a suitable "host" in which the kidneys could be grown.
The researchers collected rat embryo structures that had been genetically modified so they would not develop kidneys on their own.
The embryos were then injected with pluripotent stem cells from mice and implanted into rat wombs so they could be carried to term.
Pluripotent stem cells are a kind of "master" cell that can develop into any of the cells and tissue that make up the body.
The researchers found that the mice stem cells produced apparently functional kidneys in the rats. But the same did not hold when rat stem cells were injected into similarly modified mice embryos.
"Rat stem cells did not readily differentiate into the two main types of
cells needed for kidney formation," said Masumi Hirabayashi, an associate
professor at Japan's National Institute for Physiological Sciences, who
supervised the study.
Conversely, "mouse stem cells efficiently differentiated… forming the basic structures of a kidney," he told AFP.
The reason for the difference is still not entirely clear, but the researchers believe "environmental cues" inside the mice are likely to blame, rather than the stem cells or technique.
But even in the rat embryos, the technique was not without problems.
While the rats developed apparently functional kidneys, including with proper connections to the ureter - tubes that link the kidneys to the bladder - they died shortly after birth because they did not suckle properly.
Removing the genes that allow kidneys to develop in utero appears to have also removed their sense of smell, so the newborns failed to detect milk and died.
Their short lives meant limited testing could be done on their kidney function, but Hirabayashi said the organs appeared functional "based on anatomical observations."
There are other concerns: growing a kidney in a host from another species could lead to "contamination" of the organ with cells from the host.
And the process of growing human organs in animals poses an ethical
conundrum because human stem cells could develop into brain or reproductive
organ cells in the host.
"The main ethical concerns are the risk of consciousness and/or gamete (reproductive cell) production," said Hirabayashi. "There are serious technical barriers and complex ethical issues that must be discussed and solved before producing human organs in animals," he added.
In the short-term, additional research is likely to focus on ways to genetically modify host rats without lethal side effects.
If successful, researchers will then want to run more tests on the stem cell-derived kidneys, and try to transplant them from the hosts to other animals.
Eventually, tests could involve trying to grow human organs.
Pigs are usually considered the best hosts for human organ regeneration, but pig embryos only develop for 16 weeks, unlike the 40 weeks that human babies grow, meaning the species might not be suitable for growing organs in embryos.
Cattle, with a 40-week gestation, could be another option.
Hirabayashi said he was hopeful he would see human organs grown in animal hosts in his lifetime.
"I don't know exactly the end of my lifetime - tomorrow? Thirty years? But I very much expect to hear news regarding the practical application of animal-hosted organs."

Tariff
Add Rate

News Archive

Inside The New Nation

Cricket »

BD lose to NZ in third ODI


Sports Reporter :Despite Sabbir Rahman's century Bangladesh lost to New Zealand by 88 runs in the third and last One Day International (ODI) match at Dunedin in New Zealand on Wednesday. New Zealand clinched the ODI series 3-0.Sabbir hit a marvelous 102. His 110-ball innings was laced with 12 fours ...

Editorial »

True spirit of Ekushey must be reflected everywhere


THE nation solemnly remembers the supreme sacrifice of the valiant souls who laid down their lives to establish the right of our mother tongue Bangla as the state language of Pakistan on this day in 1952. As the pioneering movement that led to our ultimate independence, Ekushey invokes the emotional ...

International »

Palestinian President rejects tax money from Israel


Reuters, Ramallah, West Bank :The Palestinian Authority (PA) will no longer accept tax revenues collected on its behalf by Israel following its decision to trim the sum over the PA's financial support of militants' families, Palestinian President Mahmoud Abbas said.The cash-strapped Palestinian Authority, an interim self-government body set up following ...

City »

President of Bangladesh Diploma Student Nurses Union Sadia Akhter speaking at a press conference in DRU auditorium on Wednesday demanding Prime Minister Sheikh Hasina's intervention in resisting conspiracy to ruin nursing education.


.

Entertainment »

Strong and confident female characters attract Kriti Sanon


Actress Kriti Sanon is all set for a superb 2019 with Luka Chuppi, Arjun Patiala, Housefull 4 and Panipat. The characters the actress is essaying are strong-minded and confident as she is drawn towards such empowered characters. Kriti’s role in Bareilly Ki Barfi as Bitti was that of an independent ...

Editorial »

Prevent gas cylinder and pipeline explosions


GAS explosion has become very common in the country nowadays. Even if someone escapes death, the victim has to suffer burn injury or loss of valuable organs. The authorities concerned still did not take any effective step to control such incidents. In the latest incident, seven people including a couple ...

Entertainment »

Malaika Arora opens up about her divorce with Arbaaz Khan


Malaika Arora, who is recently making headlines for her relationship with Arjun Kapoor and the couples social PDA, recently opened up about her divorce with Arbaaz Khan on a radio show. Talking about her divorce she revealed that it was a mutual decision to part ways so that they could ...

City »

BNP Standing Committee Member Dr. Khondkar Mosharraf Hossain, among others, at a discussion organised by Bangladesh Jatiyatabadi Muktijoddha Dal at the Jatiya Press Club on Tuesday demanding release of BNP Chief Begum Khaleda Zia.


.

International »

Pakistan PM urges talks on Kashmir blast, warns India against attack


Reuters, Islamabad :Prime Minister Imran Khan said on Tuesday Pakistan was ready to cooperate with India in its investigation of a deadly bombing in the disputed Kashmir region last week, which India blamed on Pakistan, but warned of retaliation if attacked.Tension between the nuclear-armed neighbors has risen sharply over the ...

Sports »

Al Amin Zumar and Mukhtar Hossain of Daffodil International University receiving the championship trophy of the Inter-University Badminton Tournament and a cheque of Taka 15,000 from Dr Mohammed Farashuddin, Chairman, Board of Trustees of East West University, at the playground of East West University in the city on Monday.


.

Editorial »

Not memorization, students need analytical involvement


ABOUT one lakh students have applied to the Directorate of Primary Education (DPE) of the Primary and Mass Education Ministry for reexamination of their results, claiming that justice will be established if the authorities work properly. Some of students who failed in the examination alleged that they did not get ...

International »

`Crime may have been committed` by Trump: Ex-FBI official


AP, Washington :Former FBI Deputy Director Andrew McCabe said in an interview that aired Sunday that a "crime may have been committed" when President Donald Trump fired the head of the FBI and tried to publicly undermine an investigation into his campaign's ties to Russia. McCabe also said in the ...

Entertainment »

Moury Salim prefers challenging roles


Sheikh Arif Bulbon :Actress of present generation Moury Salim has been engaged with acting for many days. Though she has been busy with acting for long time but could not get the opportunity to work in challenging roles properly or the directors did not utilise her acting quality appropriately. On ...

Cricket »

Girona beat Real Madrid


BBC Online :Real Madrid missed the chance to go second in La Liga as Girona came from behind to record a surprise away win on Sunday.Casemiro powerfully headed in from Toni Kroos' deep cross from the right wing to give the hosts a first-half lead.Cristhian Stuani's penalty made it 1-1 ...

City »

Director General of Bangladesh Agricultural Research Institute Dr. Abul Kalam Azad speaking at the inaugural ceremony of a training programme on 'Marker Assisted Selection' at its seminar room in Gazipur on Monday.


.

 
Items that you save may be read at any time on your computer, iPad, iPhone or Android devices.
 
Are you new to our website? Do you have already an account at our website?
Create An Account Log in here
Email this news to a friend or like someone
Email:
Write a comment to this news