Home Today's Paper Most Popular Video Gallery Photo Gallery
Subscription Blog Signin Register
Logo
Thursday, June 27, 2019 01:28:30 PM
Follow Us On: Facebook Twitter Twitter Twitter Twitter

Poor sleep may up obesity risk

By
03rd-Sep-2018       
Comments
Share your thought
Post a comment »
Read all () »

Life Desk  :

People with disrupted sleep are often tired, and their body prioritizes storing fat over maintaining muscle strength which may simultaneously increase obesity risk
Lack of sleep makes it harder to process blood sugar, thereby increasing type 2 diabetes risk
Poor sleep or working night shifts may lead to excessive weight gain, reports a new study. The findings of the study are published in the scientific journal Science Advances.
In a new study, researchers at Uppsala University now demonstrate that one night of sleep loss has a tissue-specific impact on the regulation of gene expression and metabolism in humans. This may explain how shift work and chronic sleep loss impairs our metabolism and adversely affects our body composition.
'People who suffer from chronic sleep loss or who carry out night shift work are more likely to put on weight. Disrupted sleep can alter the metabolism and increases the body's ability to store fat.'
Epidemiological studies have shown that the risk for obesity and type 2 diabetes is elevated in those who suffer from chronic sleep loss or who carry out shift work. Other studies have shown an association between disrupted sleep and adverse weight gain, in which fat accumulation is increased at the same time as the muscle mass is reduced - a combination that in and of itself has been associated with numerous adverse health consequences.
Researchers from Uppsala and other groups have in earlier studies shown that metabolic functions that are regulated by, e.g., skeletal muscle and adipose tissue are adversely affected by disrupted sleep and circadian rhythms. However, until now it has remained unknown whether sleep loss per se can cause molecular changes at the tissue level that can confer an increased risk of adverse weight gain.
In the new study, the researchers studied 15 healthy normal-weight individuals who participated in two in-lab sessions in which activity and meal patterns were highly standardized.
In randomized order, the participants slept a normal night of sleep (over eight hours) during one session and were instead kept awake the entire night during the other session. The morning after each night-time intervention, small tissue samples (biopsies) were taken from the participants' subcutaneous fat and skeletal muscle. These two tissues often exhibit disrupted metabolism in conditions such as obesity and diabetes.
At the same time in the morning, blood samples were also taken to enable comparison across tissue compartments of a number of metabolites. These metabolites comprise sugar molecules, as well as different fatty and amino acids.
The tissue samples were used for multiple molecular analyses, which first of all revealed that the sleep loss condition resulted in a tissue-specific change in DNA methylation, one form of mechanism that regulates gene expression.
DNA methylation is a so-called epigenetic modification that is involved in regulating how the genes of each cell in the body are turned on or off, and is impacted by both hereditary as well as environmental factors, such as physical exercise.
"Our research group were the first to demonstrate that acute sleep loss in and of itself results in epigenetic changes in the so-called clock genes that within each tissue regulate its circadian rhythm.
Our new findings indicate that sleep loss causes tissue-specific changes to the degree of DNA methylation in genes spread throughout the human genome. Our parallel analysis of both muscle and adipose tissue further enabled us to reveal that DNA methylation is not regulated similarly in these tissues in response to acute sleep loss," said Jonathan Cedernaes who led the study.
"It is interesting that we saw changes in DNA methylation only in adipose tissue, and specifically for genes that have also been shown to be altered at the DNA methylation level in metabolic conditions such as obesity and type 2 diabetes.
Epigenetic modifications are thought to be able to confer a sort of metabolic "memory" that can regulate how metabolic programmes operate over longer time periods. We, therefore, think that the changes we have observed in our new study can constitute another piece of the puzzle of how chronic disruption of sleep and circadian rhythms may impact the risk of developing for example obesity," notes Jonathan Cedernaes.
Further analyses of, e.g., gene and protein expression demonstrated that the response as a result of wakefulness differed between skeletal muscle and adipose tissue. The researchers say that the period of wakefulness simulates the overnight wakefulness period of many shift workers assigned to night work.
A possible explanation for why the two tissues respond in an observed manner could be that overnight wakefulness periods exert a tissue-specific effect on tissues' circadian rhythm, resulting in misalignment between these rhythms. This is something that the researchers found preliminary support for also in this study, as well as in an earlier similar but smaller study.
"In the present study, we observed molecular signatures of increased inflammation across tissues in response to sleep loss. However, we also saw specific molecular signatures that indicate that the adipose tissue is attempting to increase its capacity to store fat following sleep loss, whereas we instead observed signs indicating a concomitant breakdown of skeletal muscle proteins in the skeletal muscle, in what's also known as catabolism.
We also noted changes in skeletal muscle levels of proteins involved handling blood glucose, and this could help explain why the participants' glucose sensitivity was impaired following sleep loss. Taken together, these observations may provide at least partial mechanistic insight as to why chronic sleep loss and shift work can increase the risk of adverse weight gain as well as the risk of type 2 diabetes," said Jonathan Cedernaes.
The researchers have only studied the effect of one night of sleep loss, and therefore do not know how other forms of sleep or disruption of circadian misalignment would have affected the participants' tissue metabolism.
"It will be interesting to investigate to what extent one or more nights of recovery sleep can normalize the metabolic changes that we observe at the tissue level as a result of sleep loss. Diet and exercise are factors that can also alter DNA methylation, and these factors can thus possibly be used to counteract adverse metabolic effects of sleep loss," said Jonathan Cedernaes.
Source: Eurekalert

Tariff
Add Rate

News Archive

Inside The New Nation

Cricket »

Clive Lloyd calls for West Indies tons to match talent after World Cup woe


Clive Lloyd has called on the current crop of West Indies cricketers to add application to their talent after a disappointing World Cup campaign so far.The West Indies have won just one of their opening six games in England and look almost certain to miss out on the semi-finals."West Indies ...

Business & Economy »

NRBC launches mobile banking app "Planet"


Staff Reporter :NRB Commercial Bank (NRBC) Limited on Wednesday launched its mobile banking app "NRBC PLANET" to bring comfort and mobility in the banking services. The app was launched at a ceremony held at the bank's head office in the city.Sheikh Fazle Fahim, President of FBCCI, attended the ceremony as ...

Entertainment »

Kona again as judge in a reality show


Sheikh Arif Bulbon :Last year RTV started a new reality show titled Campus Star to discover talented youngsters in music, dance and acting. This year its new season is set to kick off soon. Popular singer Dilshad Nahar Kona will be also seen playing the role of a judge in ...

Entertainment »

No love triangle in Dabangg 3: Sonakshi Sinha


Actress Sonakshi Sinha, who is reprising her role as Rajjo in Dabangg 3, says there will be no love triangle in the upcoming instalment of the movie. Sonakshi spoke about it at the launch of salon brand Streax Professional’s retro remix collection on Monday. There has been buzz that Dabangg ...

Editorial »

Keep liver transplant affordable


IN the latest development, surgeons at Bangabandhu Sheikh Mujib Medical University have successfully performed liver transplant at a government hospital for the first time. Media on Tuesday reported that, a team of 50 doctors conducted simultaneous surgeries on a 20-year-old man and his 47-year-old mother, who donated a portion of ...

International »

Shocking photos of drowned Salvadoran father and child spark outrage


AFP, Ciudad Victoria, Mexico :Shocking images of a drowned Salvadoran migrant and his two-year-old daughter who died while trying to cross the Rio Grande river from Mexico to the United States have sparked outrage, underscoring the dangers faced by asylum-seekers.Twenty-five-year-old Oscar Martinez Ramirez fled El Salvador with his 21-year-old wife ...

International »

Iran 'never seeks war' with US, says Rouhani


AFP :Iran "never seeks war" with the United States, President Hassan Rouhani said as he sought to rein in soaring tensions Wednesday between the two countries."Iran has no interest to increase tension in the region and it never seeks war with any country, including (the) US," the president said, quoted ...

Cricket »

Shakib now eying to beat India


Bangladesh ace all-rounder Shakib Al Hasan knows, beating an inform India will be a tough proposition but he refuses to give up hopes, saying that they would come all guns blazing against the sub-continent giants when they take them on July 2 at Birmingham.After reviving the side's semifinal hope, beating ...

International »

Venezuela's former spy chief says Maduro could yet fall


AFP :Venezuela's former intelligence chief, Cristopher Figuera, who fled the country after backing a failed uprising against President Nicolas Maduro in April, has told the Washington Post the regime could still fall."I'm proud of what I did," he said in an interview published online late Monday. "For now, the regime ...

International »

Russian, North American astronauts return to earth


AFP :The first crew to blast off to the International Space Station following a launch accident that deepened doubts over Russia's space programme returned to earth safely on Tuesday.NASA astronaut Anne McClain, veteran cosmonaut Oleg Kononenko of Roscosmos, and Canadian Space Agency record-holder David Saint-Jacques emerged from the space craft ...

Editorial »

Food adulteration business must stop


RESEARCHERS at Dhaka University on Tuesday said all the samples of milk products; edible oils and spices they tested were substandard. According to newspaper reports, they have found traces of detergent in pasteurised milk produced by five companies -- Pran, Milk Vita, Igloo, Aarong, and Farm Fresh. The DU researchers ...

Entertainment »

Mimi`s heartwarming wish for newly-wed Nusrat


No wonder Nusrat Jahan and Nikhil Jain's destination wedding in the picturesque town of Bodrum in Turkey became the talk of the town over the last two weeks. Tolly actress and newly elected MP Nusrat got hitched to Kolkata-based businessman Nikhil Jain on June 19. It was a cosy family ...

Editorial »

Train accident: Responsible persons must be punished


AT least five people, including three women, were killed and more than 100 injured as the Upaban Express -- a passenger train heading to the capital from Sylhet -- derailed on a bridge in Moulvibazar on Sunday night. One of the carriages of it fell into a canal while two ...

Entertainment »

Shirin Shila`s Lady Action


Sheikh Arif Bulbon :With the inspiration and assistance from noted film actress Rasheda Chowdhury Shirin Shila started her journey in film industry. Before starting acting in big screen Shila acted with Rasheda Chowdhury in a drama. Basically Rasheda Chowdhury inspired Shila to work in movie. Once she also introduced Shila ...

Cricket »

Shakib first Bangladeshi batsman to complete 1000 WC runs


Talismanic all-rounder Shakib Al Hasan became the first Bangladeshi batsman to complete 1000 runs in the World Cup during the match against Afghanistan at the Rose Bowl in Southampton on Monday.Starting the match with 965 runs and 35 runs shy of achieve the feat, Shakib flicked pace bowler Dawlat Zadran ...

 
Items that you save may be read at any time on your computer, iPad, iPhone or Android devices.
 
Are you new to our website? Do you have already an account at our website?
Create An Account Log in here
Email this news to a friend or like someone
Email:
Write a comment to this news